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KMID : 1137020110220030188
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Journal of Gynecologic Oncology
2011 Volume.22 No. 3 p.188 ~ p.195
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Clinicopathologic characteristics of granulosa cell tumors of the ovary: a multicenter retrospective study
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Lee In-Ho
Choi Chel-Hun
Hong Dae-Gy
Song Jae-Yun
Kim Young-Jae
Kim Kyung-Tai
Lee Kyu-Wan
Park Il-Soo
Bae Duk-Soo
Kim Tae-Jin
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Abstract
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Objective: To evaluate the clinicopathologic characteristics and prognostic factors of ovarian granulosa cell tumors.
Methods: Medical records of 113 patients presenting between January 1995 and December 2007 were retrospectively reviewed.
Results: One-hundred two patients had adult type disease, with a mean age of 46.2 years (range, 18 to 83 years) and a mean follow-up period of 54.7 months (range, 1 to 155 months). The distribution of FIGO stages was 86 patients at stage I, 11 at stage II, and 5 at stage III. During follow-up, ten patients recurred at a mean time of 48 months (range, 4 to 109 months). Among them, three patients died after a mean of 57 months (range, 25 to 103 months). In recurrence analysis, advanced stage (p=0.032) and presence of residual disease (p=0.012) were statistically significant, and age<40 years, premenopause and positive washing cytology were marginally significant (p<0.1). In multivariate analysis, stage was the only factor associated with recurrence; adjuvant chemotherapy and fertility-sparing surgery were not statistically significant. Among 36 patients with fertility-sparing operations, eight patients had nine pregnancies and delivered seven babies. Eleven patients had juvenile type tumors; the mean age was 20.0 years (range, 8 to 45 years) and the mean follow-up period was 69.8 months (range, 20 to 156 months). The distribution of FIGO stage was nine patients at stage I and two at stage III. There were no recurrences or deaths reported. Four patients had seven pregnancies and delivered six babies.
Conclusion: Stage is the only factor associated with disease-free survival, and fertility-sparing surgery may be a treatment option for women with early-stage disease who want to retain fertility.
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KEYWORD
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Clinical study, Granulosa cell tumor, Ovary, Pregnancy, Recurrence
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